Among patients with severe or life-threatening COVID-19, convalescent plasma therapy added to standard treatment, compared with standard treatment alone, did not result in a statistically significant improvement in time to clinical improvement within 28 days. Interpretation is limited by early termination of the trial, which may have been underpowered to detect a clinically important difference.
The coronavirus outbreak began in December 2019 in Wuhan, the capital of Hubei Province and the largest city in central China with a population of around 11 million. Epidemiologists have traced the likely source of the outbreak to the Huanan Seafood Wholesale Market in downtown Wuhan, where they believe the virus was initially transmitted from animals to humans.
On January 23, authorities placed Wuhan under quarantine, suspending all flights, trains, and long-haul buses into and out of the city. The World Health Organization commended the move, which was unprecedented in its scale.
By the end of January, authorities had enforced transportation restrictions in at least 15 additional cities in Hubei Province. Together, over 57 million people in China have been affected by the quarantines.
STORYMAP: ESRI’s StoryMap Team