Thirty five-year-old man with 2019-novel coronavirus pneumonia.
A–D. Axial computed tomography (CT) images of upper, middle, and lower lobes of right lung and lower lobe of left lung show multifocal regions of patchy consolidation and nodular ground-glass opacities, mainly distributed along bronchial bundles and subpleural regions. E. Coronal reformation CT image shows multifocal nodular ground glass opacities in right lower lung lobe.
ORIGINAL REPORT: Korean Journal of Radiology
Thirty nine-year-old man with 2019-novel coronavirus pneumonia. High-resolution computed tomography images show ill-defined focal consolidation (arrow) along bronchovascular bundles in right lower lung lobe (A) and ill-defined ground-glass opacities (arrow) in subpleural regions of left lower lung lobe (B).
SOURCE: Korean Journal of Radiology
Patients with severe respiratory viral infections requiring ICU care present typically with hypoxemic respiratory failure. Oseltamivir is the most widely used neuraminidase inhibitor for treatment of influenza; data suggest that early use is associated with reduced mortality in critically ill patients with influenza. At present, there are no antiviral therapies of proven efficacy for other severe respiratory viral infections.
Several adjunctive pharmacologic interventions have been studied for their immunomodulatory effects, including macrolides, corticosteroids, cyclooxygenase-2 inhibitors, sirolimus, statins, anti-influenza immune plasma, and vitamin C, but none is recommended at present in severe respiratory viral infections. Evidence-based supportive care is the mainstay for management of severe respiratory viral infection.
Non-invasive ventilation in patients with severe respiratory viral infections causing acute hypoxemic respiratory failure and pneumonia is associated with a high likelihood of transition to invasive ventilation.
SOURCE: Intensive Care Medicine